Cargando…

Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis

Accumulating evidence suggests that gut bacteria play a role in homeostasis of the circulatory system in mammals. First, gut bacteria may affect the nervous control of the circulatory system via the sensory fibres of the enteric nervous system. Second, gut bacteria-derived metabolites may cross the...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomasova, Lenka, Konopelski, Piotr, Ufnal, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273628/
https://www.ncbi.nlm.nih.gov/pubmed/27869680
http://dx.doi.org/10.3390/molecules21111558
_version_ 1783377431016505344
author Tomasova, Lenka
Konopelski, Piotr
Ufnal, Marcin
author_facet Tomasova, Lenka
Konopelski, Piotr
Ufnal, Marcin
author_sort Tomasova, Lenka
collection PubMed
description Accumulating evidence suggests that gut bacteria play a role in homeostasis of the circulatory system in mammals. First, gut bacteria may affect the nervous control of the circulatory system via the sensory fibres of the enteric nervous system. Second, gut bacteria-derived metabolites may cross the gut-blood barrier and target blood vessels, the heart and other organs involved in the regulation of the circulatory system. A number of studies have shown that hydrogen sulfide (H(2)S) is an important biological mediator in the circulatory system. Thus far, research has focused on the effects of H(2)S enzymatically produced by cardiovascular tissues. However, some recent evidence indicates that H(2)S released in the colon may also contribute to the control of arterial blood pressure. Incidentally, sulfate-reducing bacteria are ubiquitous in mammalian colon, and H(2)S is just one among a number of molecules produced by the gut flora. Other gut bacteria-derived compounds that may affect the circulatory system include methane, nitric oxide, carbon monoxide, trimethylamine or indole. In this paper, we review studies that imply a role of gut microbiota and their metabolites, such as H(2)S, in circulatory system homeostasis.
format Online
Article
Text
id pubmed-6273628
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62736282018-12-28 Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis Tomasova, Lenka Konopelski, Piotr Ufnal, Marcin Molecules Review Accumulating evidence suggests that gut bacteria play a role in homeostasis of the circulatory system in mammals. First, gut bacteria may affect the nervous control of the circulatory system via the sensory fibres of the enteric nervous system. Second, gut bacteria-derived metabolites may cross the gut-blood barrier and target blood vessels, the heart and other organs involved in the regulation of the circulatory system. A number of studies have shown that hydrogen sulfide (H(2)S) is an important biological mediator in the circulatory system. Thus far, research has focused on the effects of H(2)S enzymatically produced by cardiovascular tissues. However, some recent evidence indicates that H(2)S released in the colon may also contribute to the control of arterial blood pressure. Incidentally, sulfate-reducing bacteria are ubiquitous in mammalian colon, and H(2)S is just one among a number of molecules produced by the gut flora. Other gut bacteria-derived compounds that may affect the circulatory system include methane, nitric oxide, carbon monoxide, trimethylamine or indole. In this paper, we review studies that imply a role of gut microbiota and their metabolites, such as H(2)S, in circulatory system homeostasis. MDPI 2016-11-17 /pmc/articles/PMC6273628/ /pubmed/27869680 http://dx.doi.org/10.3390/molecules21111558 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tomasova, Lenka
Konopelski, Piotr
Ufnal, Marcin
Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title_full Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title_fullStr Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title_full_unstemmed Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title_short Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
title_sort gut bacteria and hydrogen sulfide: the new old players in circulatory system homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273628/
https://www.ncbi.nlm.nih.gov/pubmed/27869680
http://dx.doi.org/10.3390/molecules21111558
work_keys_str_mv AT tomasovalenka gutbacteriaandhydrogensulfidethenewoldplayersincirculatorysystemhomeostasis
AT konopelskipiotr gutbacteriaandhydrogensulfidethenewoldplayersincirculatorysystemhomeostasis
AT ufnalmarcin gutbacteriaandhydrogensulfidethenewoldplayersincirculatorysystemhomeostasis