Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

A series of new conjugated compounds with a –SCH(2)– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC(50) values (5.1–8.4 μM...

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Detalles Bibliográficos
Autores principales: Tsay, Shwu-Chen, Lin, Shu-Yu, Huang, Wen-Chieh, Hsu, Ming-Hua, Hwang, Kuo Chu, Lin, Chun-Cheng, Horng, Jia-Cherng, Chen, I-Chia, Hwu, Jih Ru, Shieh, Fa-Kuen, Leyssen, Pieter, Neyts, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273635/
https://www.ncbi.nlm.nih.gov/pubmed/26901180
http://dx.doi.org/10.3390/molecules21020228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273635/
https://www.ncbi.nlm.nih.gov/pubmed/26901180
http://dx.doi.org/10.3390/molecules21020228

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