A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been fo...

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Autores principales: Dai, Ying-Hui, Shen, Bo, Xia, Ming-Yu, Wang, An-Dong, Chen, Yu-Lin, Liu, Dong-Chun, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273675/
https://www.ncbi.nlm.nih.gov/pubmed/26999086
http://dx.doi.org/10.3390/molecules21030349
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author Dai, Ying-Hui
Shen, Bo
Xia, Ming-Yu
Wang, An-Dong
Chen, Yu-Lin
Liu, Dong-Chun
Wang, Dong
author_facet Dai, Ying-Hui
Shen, Bo
Xia, Ming-Yu
Wang, An-Dong
Chen, Yu-Lin
Liu, Dong-Chun
Wang, Dong
author_sort Dai, Ying-Hui
collection PubMed
description A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities.
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spelling pubmed-62736752018-12-28 A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans Dai, Ying-Hui Shen, Bo Xia, Ming-Yu Wang, An-Dong Chen, Yu-Lin Liu, Dong-Chun Wang, Dong Molecules Article A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities. MDPI 2016-03-16 /pmc/articles/PMC6273675/ /pubmed/26999086 http://dx.doi.org/10.3390/molecules21030349 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dai, Ying-Hui
Shen, Bo
Xia, Ming-Yu
Wang, An-Dong
Chen, Yu-Lin
Liu, Dong-Chun
Wang, Dong
A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title_full A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title_fullStr A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title_full_unstemmed A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title_short A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans
title_sort new indole alkaloid from the toad venom of bufo bufo gargarizans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273675/
https://www.ncbi.nlm.nih.gov/pubmed/26999086
http://dx.doi.org/10.3390/molecules21030349
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