Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides

The efficiency of direct conversion of tertiary alcohols bearing a β-hydrogen atom to vicinal halohydrins—chlorohydrins and bromohydrins—under green reaction conditions was tested preliminarily on model tertiary benzyl alcohols. Tertiary alcohols were successfully directly halogenated to vicinal hal...

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Detalles Bibliográficos
Autores principales: Ajvazi, Njomza, Stavber, Stojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273677/
https://www.ncbi.nlm.nih.gov/pubmed/27706096
http://dx.doi.org/10.3390/molecules21101325
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author Ajvazi, Njomza
Stavber, Stojan
author_facet Ajvazi, Njomza
Stavber, Stojan
author_sort Ajvazi, Njomza
collection PubMed
description The efficiency of direct conversion of tertiary alcohols bearing a β-hydrogen atom to vicinal halohydrins—chlorohydrins and bromohydrins—under green reaction conditions was tested preliminarily on model tertiary benzyl alcohols. Tertiary alcohols were successfully directly halogenated to vicinal halohydrins with N-halosuccinimide in aqueous media. The efficiency of the reaction in water was significantly improved in the presence of sodium dodecyl sulphate as the surfactant.
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spelling pubmed-62736772018-12-28 Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides Ajvazi, Njomza Stavber, Stojan Molecules Article The efficiency of direct conversion of tertiary alcohols bearing a β-hydrogen atom to vicinal halohydrins—chlorohydrins and bromohydrins—under green reaction conditions was tested preliminarily on model tertiary benzyl alcohols. Tertiary alcohols were successfully directly halogenated to vicinal halohydrins with N-halosuccinimide in aqueous media. The efficiency of the reaction in water was significantly improved in the presence of sodium dodecyl sulphate as the surfactant. MDPI 2016-10-02 /pmc/articles/PMC6273677/ /pubmed/27706096 http://dx.doi.org/10.3390/molecules21101325 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ajvazi, Njomza
Stavber, Stojan
Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title_full Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title_fullStr Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title_full_unstemmed Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title_short Transformation of Tertiary Benzyl Alcohols into the Vicinal Halo-Substituted Derivatives Using N-Halosuccinimides
title_sort transformation of tertiary benzyl alcohols into the vicinal halo-substituted derivatives using n-halosuccinimides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273677/
https://www.ncbi.nlm.nih.gov/pubmed/27706096
http://dx.doi.org/10.3390/molecules21101325
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AT stavberstojan transformationoftertiarybenzylalcoholsintothevicinalhalosubstitutedderivativesusingnhalosuccinimides

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