Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH(2)Cl(2)-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using s...

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Detalles Bibliográficos
Autores principales: Torres-Mendoza, Daniel, González, Yisett, Gómez-Reyes, José Félix, Guzmán, Héctor M., López-Perez, José Luis, Gerwick, William H., Fernandez, Patricia L., Gutiérrez, Marcelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273691/
https://www.ncbi.nlm.nih.gov/pubmed/27338338
http://dx.doi.org/10.3390/molecules21060819
Descripción
Sumario:Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH(2)Cl(2)-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.

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