Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH(2)Cl(2)-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using s...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres-Mendoza, Daniel, González, Yisett, Gómez-Reyes, José Félix, Guzmán, Héctor M., López-Perez, José Luis, Gerwick, William H., Fernandez, Patricia L., Gutiérrez, Marcelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273691/
https://www.ncbi.nlm.nih.gov/pubmed/27338338
http://dx.doi.org/10.3390/molecules21060819
_version_ 1783377445640994816
author Torres-Mendoza, Daniel
González, Yisett
Gómez-Reyes, José Félix
Guzmán, Héctor M.
López-Perez, José Luis
Gerwick, William H.
Fernandez, Patricia L.
Gutiérrez, Marcelino
author_facet Torres-Mendoza, Daniel
González, Yisett
Gómez-Reyes, José Félix
Guzmán, Héctor M.
López-Perez, José Luis
Gerwick, William H.
Fernandez, Patricia L.
Gutiérrez, Marcelino
author_sort Torres-Mendoza, Daniel
collection PubMed
description Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH(2)Cl(2)-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.
format Online
Article
Text
id pubmed-6273691
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62736912018-12-28 Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea Torres-Mendoza, Daniel González, Yisett Gómez-Reyes, José Félix Guzmán, Héctor M. López-Perez, José Luis Gerwick, William H. Fernandez, Patricia L. Gutiérrez, Marcelino Molecules Article Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH(2)Cl(2)-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1–3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages. MDPI 2016-06-22 /pmc/articles/PMC6273691/ /pubmed/27338338 http://dx.doi.org/10.3390/molecules21060819 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torres-Mendoza, Daniel
González, Yisett
Gómez-Reyes, José Félix
Guzmán, Héctor M.
López-Perez, José Luis
Gerwick, William H.
Fernandez, Patricia L.
Gutiérrez, Marcelino
Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title_full Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title_fullStr Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title_full_unstemmed Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title_short Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
title_sort uprolides n, o and p from the panamanian octocoral eunicea succinea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273691/
https://www.ncbi.nlm.nih.gov/pubmed/27338338
http://dx.doi.org/10.3390/molecules21060819
work_keys_str_mv AT torresmendozadaniel uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT gonzalezyisett uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT gomezreyesjosefelix uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT guzmanhectorm uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT lopezperezjoseluis uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT gerwickwilliamh uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT fernandezpatricial uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea
AT gutierrezmarcelino uprolidesnoandpfromthepanamanianoctocoraleuniceasuccinea

Ejemplares similares