Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate). Based on its indispensability for pathogenic parasites from the genus Trypanosoma, G6PDH is considered...

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Detalles Bibliográficos
Autores principales: Ortiz, Cecilia, Moraca, Francesca, Medeiros, Andrea, Botta, Maurizio, Hamilton, Niall, Comini, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273692/
https://www.ncbi.nlm.nih.gov/pubmed/26999093
http://dx.doi.org/10.3390/molecules21030368

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