In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The ac...

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Autores principales: Leliebre-Lara, Vivian, Monzote Fidalgo, Lianet, Pferschy-Wenzig, Eva-Maria, Kunert, Olaf, Nogueiras Lima, Clara, Bauer, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273698/
https://www.ncbi.nlm.nih.gov/pubmed/27517895
http://dx.doi.org/10.3390/molecules21081045
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author Leliebre-Lara, Vivian
Monzote Fidalgo, Lianet
Pferschy-Wenzig, Eva-Maria
Kunert, Olaf
Nogueiras Lima, Clara
Bauer, Rudolf
author_facet Leliebre-Lara, Vivian
Monzote Fidalgo, Lianet
Pferschy-Wenzig, Eva-Maria
Kunert, Olaf
Nogueiras Lima, Clara
Bauer, Rudolf
author_sort Leliebre-Lara, Vivian
collection PubMed
description Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC(50) promastigotes 2.9 ± 0.1 μM and IC(50) amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.
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spelling pubmed-62736982018-12-28 In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden) Leliebre-Lara, Vivian Monzote Fidalgo, Lianet Pferschy-Wenzig, Eva-Maria Kunert, Olaf Nogueiras Lima, Clara Bauer, Rudolf Molecules Communication Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC(50) promastigotes 2.9 ± 0.1 μM and IC(50) amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity. MDPI 2016-08-10 /pmc/articles/PMC6273698/ /pubmed/27517895 http://dx.doi.org/10.3390/molecules21081045 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Leliebre-Lara, Vivian
Monzote Fidalgo, Lianet
Pferschy-Wenzig, Eva-Maria
Kunert, Olaf
Nogueiras Lima, Clara
Bauer, Rudolf
In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title_full In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title_fullStr In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title_full_unstemmed In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title_short In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)
title_sort in vitro antileishmanial activity of sterols from trametes versicolor (bres. rivarden)
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273698/
https://www.ncbi.nlm.nih.gov/pubmed/27517895
http://dx.doi.org/10.3390/molecules21081045
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