Cargando…

Synthesis and Evaluation of Novel α-Aminoamides Containing an Indole Moiety for the Treatment of Neuropathic Pain

The α-aminoamide family of sodium ion channel blockers have exhibited analgesic effects on neuropathic pain. Here, a series of novel α-aminoamides containing an indole ring were designed and synthesized. These compounds were evaluated in mice using a formalin test and they exhibited significant anti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Haotian, Fan, Shiyong, Cheng, Jingchao, Zhang, Ping, Zhong, Bohua, Shi, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273711/ https://www.ncbi.nlm.nih.gov/pubmed/27347907 http://dx.doi.org/10.3390/molecules21070793

Ejemplares similares

Synthesis and Evaluation of Novel α-Aminoamides Containing Benzoheterocyclic Moiety for the Treatment of Pain
por: Tong, Kun, et al.
Publicado: (2021)

Synthesis and Transformation of (-)-Isopulegol-Based Chiral β-Aminolactones and β-Aminoamides
por: Le, Tam Minh, et al.
Publicado: (2018)

Base-Free Synthesis and Photophysical Properties of New Schiff Bases Containing Indole Moiety
por: Soliman, Ahmed I. A., et al.
Publicado: (2022)

Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility
por: Sung, Hui-Jin, et al.
Publicado: (2012)

Synthesis of indole derivatives as prevalent moieties present in selected alkaloids
por: Heravi, Majid M., et al.
Publicado: (2021)

DMSO–allyl bromide: a mild and efficient reagent for atom economic one-pot N-allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles
por: Smile, Suresh Snoxma, et al.
Publicado: (2022)

Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations
por: Younis, Osama, et al.
Publicado: (2022)

Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists
por: Ma, Mengjun, et al.
Publicado: (2019)

Synthesis of Novel α-Trifluorothioanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

Synthesis of Novel α-Trifluoroanisole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs
por: Zhou, Mo, et al.
Publicado: (2014)

Synthesis of adenosine analogues with indole moiety as human adenosine A(3) receptor ligands
por: Xia, Yan, et al.
Publicado: (2018)

Late‐Stage Chemoenzymatic Installation of Hydroxy‐Bearing Allyl Moiety on the Indole Ring of Tryptophan‐Containing Peptides
por: Mupparapu, Nagaraju, et al.
Publicado: (2022)

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
por: Sansook, Supojjanee, et al.
Publicado: (2017)

Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties
por: Karekal, Mahendra Raj, et al.
Publicado: (2013)

Synthesis and Antiviral Bioactivity of Chiral Thioureas Containing Leucine and Phosphonate Moieties
por: Liu, Jingzi, et al.
Publicado: (2010)

Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta
por: Ok, Seong-Ho, et al.
Publicado: (2013)

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety
por: Wu, Wenneng, et al.
Publicado: (2021)

Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety
por: Sansook, Supojjanee, et al.
Publicado: (2017)

Chemoenzymatic Synthesis of Indole-Containing Acyloin Derivatives
por: Alrashdi, Saad, et al.
Publicado: (2023)

Microwave-Assisted N-Allylation/Homoallylation-RCM Approach: Access to Pyrrole-, Pyridine-, or Azepine-Appended (Het)aryl Aminoamides
por: Novanna, Motakatla, et al.
Publicado: (2020)

Synthesis and Insecticidal Activity of Mesoionic Pyrido[1,2-α]pyrimidinone Derivatives Containing a Neonicotinoid Moiety
por: Pan, Jianke, et al.
Publicado: (2018)

A magnetic porous organic polymer: catalytic application in the synthesis of hybrid pyridines with indole, triazole and sulfonamide moieties
por: Torabi, Morteza, et al.
Publicado: (2022)

Synthesis and Antibacterial Activity of Novel Curcumin Derivatives Containing Heterocyclic Moiety
por: A. Hamed, Othman, et al.
Publicado: (2013)

Solid-phase synthesis of peptides containing aminoadipic semialdehyde moiety and their cyclisations
por: Kijewska, Monika, et al.
Publicado: (2018)

Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety
por: Chen, Hong, et al.
Publicado: (2017)

Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety
por: Wang, Yanwei, et al.
Publicado: (2014)

Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs
por: Shao, Pingxuan, et al.
Publicado: (2019)

Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety
por: Cui, Peipei, et al.
Publicado: (2022)

Design, Synthesis, and Antitumor Activity of Olmutinib Derivatives Containing Acrylamide Moiety
por: Hu, Xiaohan, et al.
Publicado: (2021)

Synthesis of Novel Pyrazole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
por: Cai, Zengfei, et al.
Publicado: (2022)

Design, synthesis and fungicidal evaluation of novel psoralen derivatives containing sulfonohydrazide or acylthiourea moiety
por: Dong, Jingyue, et al.
Publicado: (2022)

Alterations in Red Blood Cell Functionality Induced by an Indole Scaffold Containing a Y-Iminodiketo Moiety: Potential Antiproliferative Conditions
por: Scala, Angela, et al.
Publicado: (2016)

Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety
por: Dai, Hong, et al.
Publicado: (2016)

Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters
por: Gavin, Joshua T., et al.
Publicado: (2018)

Design, Synthesis, and Antifungal Activity of Some Novel Phenylthiazole Derivatives Containing an Acylhydrazone Moiety
por: Tian, Yao, et al.
Publicado: (2023)

Design, synthesis and screening of indole acetic acid-based tri-azo moieties as antioxidants, anti-microbial and cytotoxic agents
por: Javaid, Maryam, et al.
Publicado: (2023)

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII
por: Demir-Yazıcı, Kübra, et al.
Publicado: (2019)

TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors
por: Cui, Huifei, et al.
Publicado: (2023)

Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety
por: Wu, Jian, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mf5i9aepjoag2c1lsopv7fa02m