Cargando…

Treatment with Akebia Saponin D Ameliorates Aβ(1–42)-Induced Memory Impairment and Neurotoxicity in Rats

Amyloid-β peptide (Aβ) is known to be directly associated with the progressive neuronal death observed in Alzheimer’s disease (AD). However, effective neuroprotective approaches against Aβ neurotoxicity are still unavailable. In the present study, we investigated the protective effects of Akebia sap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yongde, Yang, Xiaolin, Chen, Tong, Ji, Jing, Lan, Li, Hu, Rong, Ji, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Conference Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273713/ http://dx.doi.org/10.3390/molecules21030323

Ejemplares similares

Akebia Saponin D Regulates the Metabolome and Intestinal Microbiota in High Fat Diet-Induced Hyperlipidemic Rats
por: Zhou, Peipei, et al.
Publicado: (2019)

Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata
por: Xu, Qiao-Lin, et al.
Publicado: (2016)

Industrial-Scale Preparation of Akebia Saponin D by a Two-Step Macroporous Resin Column Separation
por: Wu, Yue, et al.
Publicado: (2012)

Preparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D–phospholipid complex
por: Shen, Jinyang, et al.
Publicado: (2016)

Panax Notoginseng Saponins Ameliorate Aβ-Mediated Neurotoxicity in C. elegans through Antioxidant Activities
por: Zhou, Ling, et al.
Publicado: (2019)

Administration of Akebia Saponin D Improved Blood Lipid Levels and Pregnancy Outcomes in Mice with Gestational Diabetes Mellitus
por: Chen, Wei, et al.
Publicado: (2023)

Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in mice through the PI3K-Akt pathway
por: Liu, Qin, et al.
Publicado: (2022)

Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia
por: WANG, JINGHUA, et al.
Publicado: (2014)

Akebia Saponin D prevents axonal loss against TNF-induced optic nerve damage with autophagy modulation
por: Sase, Kana, et al.
Publicado: (2020)

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway
por: Li, Pengfei, et al.
Publicado: (2021)

RRY Inhibits Amyloid-β(1–42) Peptide Aggregation and Neurotoxicity
por: Sun, Xicui, et al.
Publicado: (2021)

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment
por: Bellozi, Paula Maria Quaglio, et al.
Publicado: (2016)

Xanthoceraside Ameliorates Mitochondrial Dysfunction Contributing to the Improvement of Learning and Memory Impairment in Mice with Intracerebroventricular Injection of Aβ1-42
por: Ji, Xue-Fei, et al.
Publicado: (2014)

Ameliorating effects of aged garlic extracts against Aβ-induced neurotoxicity and cognitive impairment
por: Jeong, Ji Hee, et al.
Publicado: (2013)

Identification and Characterization of NBS Resistance Genes in Akebia trifoliata
por: Yu, Xiaojiao, et al.
Publicado: (2021)

Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ(1-42)-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells
por: Yang, Bing-You, et al.
Publicado: (2018)

Endocytic pathways mediating oligomeric Aβ42 neurotoxicity
por: Yu, Chunjiang, et al.
Publicado: (2010)

Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ (1–42)-Induced Memory Impairment in Mice
por: Hu, Di, et al.
Publicado: (2012)

Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1–42 in Mice
por: Koh, Eun-Jeong, et al.
Publicado: (2017)

The complete chloroplast genome of Akebia longeracemosa (Lardizabalaceae)
por: Xiao, Xiong, et al.
Publicado: (2021)

Ameliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products
por: Shin, Seoungwoo, et al.
Publicado: (2015)

Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway
por: Luo, Jin-Fang, et al.
Publicado: (2022)

Conformational Essentials Responsible for Neurotoxicity of Aβ42 Aggregates Revealed by Antibodies against Oligomeric Aβ42
por: Song, Chuli, et al.
Publicado: (2022)

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β(1-42)
por: Bate, Clive, et al.
Publicado: (2004)

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010)

Effects of climate change on the distribution of wild Akebia trifoliata
por: Zhang, Jun‐Ming, et al.
Publicado: (2022)

Diammonium Glycyrrhizinate Upregulates PGC-1α and Protects against Aβ(1–42)-Induced Neurotoxicity
por: Zhu, Xiaolei, et al.
Publicado: (2012)

Science & Art at the 42nd International Hot-Air Balloon Festival and the Balloon Museum in Château-d'Oex
por: Beck, Hans Peter
Publicado: (2020)

Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment
por: Liu, Pengfei, et al.
Publicado: (2021)

Bioactive 30-Noroleanane Triterpenes from the Pericarps of Akebia trifoliata
por: Wang, Jing, et al.
Publicado: (2014)

The complete chloroplast genome of Akebia quinata (Lardizabalaceae) and phylogenetic analysis
por: Min, Jie, et al.
Publicado: (2020)

UX: Memory and usability
por: Wallet, Bas
Publicado: (2018)

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways
por: Ji, Yun-Jeong, et al.
Publicado: (2021)

Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia
por: Zhu, Ning-Wei, et al.
Publicado: (2019)

Akebia saponin D acts via the PPAR‐gamma pathway to reprogramme a pro‐neurogenic microglia that can restore hippocampal neurogenesis in mice exposed to chronic mild stress
por: Zhang, Jinqiang, et al.
Publicado: (2023)

FcgRIIb mediates amyloid-β neurotoxicity and memory impairment in a model of Alzheimer’s disease
por: Jung, Yong-Keun
Publicado: (2013)

Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ(1–42) Oligomer-Induced Memory Impairment in Mice
por: Ko, Sang Yoon, et al.
Publicado: (2015)

Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease
por: Zhao, Yuequan, et al.
Publicado: (2021)

The Protective Effects of Zeaxanthin on Amyloid-β Peptide 1–42-Induced Impairment of Learning and Memory Ability in Rats
por: Li, Xiaoying, et al.
Publicado: (2022)

Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β(1–42) Oligomers
por: Wang, Li-Sha, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l01kl3qh1foeuqbdu66273qhql