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The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice

Acute respiratory distress syndrome (ARDS),which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the morta...

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Autores principales: Xu, Xiaohan, Liu, Ning, Zhang, Yu-Xin, Cao, Jinjin, Wu, Donglin, Peng, Qisheng, Wang, Hong-Bing, Sun, Wan-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273719/
https://www.ncbi.nlm.nih.gov/pubmed/26760995
http://dx.doi.org/10.3390/molecules21010077
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author Xu, Xiaohan
Liu, Ning
Zhang, Yu-Xin
Cao, Jinjin
Wu, Donglin
Peng, Qisheng
Wang, Hong-Bing
Sun, Wan-Chun
author_facet Xu, Xiaohan
Liu, Ning
Zhang, Yu-Xin
Cao, Jinjin
Wu, Donglin
Peng, Qisheng
Wang, Hong-Bing
Sun, Wan-Chun
author_sort Xu, Xiaohan
collection PubMed
description Acute respiratory distress syndrome (ARDS),which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the mortality is high. Thus, there is a tremendous need for new therapies. We have reported that HJB-1, a 17-hydroxy-jolkinolide B derivative, exhibited strong anti-inflammatory effects in vitro. In this study, we investigated its impacts on LPS-induced ARDS mice. We found that HJB-1 significantly alleviated LPS-induced pulmonary histological alterations, inflammatory cells infiltration, lung edema, as well as the generation of inflammatory cytokines TNF-α, IL-1β and IL-6 in BALF. In addition, HJB-1 markedly suppressed LPS-induced IκB-α degradation, nuclear accumulation of NF-κB p65 subunit and MAPK phosphorylation. These results suggested that HJB-1 improved LPS-induced ARDS by suppressing LPS-induced NF-κB and MAPK activation.
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spelling pubmed-62737192018-12-28 The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice Xu, Xiaohan Liu, Ning Zhang, Yu-Xin Cao, Jinjin Wu, Donglin Peng, Qisheng Wang, Hong-Bing Sun, Wan-Chun Molecules Article Acute respiratory distress syndrome (ARDS),which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the mortality is high. Thus, there is a tremendous need for new therapies. We have reported that HJB-1, a 17-hydroxy-jolkinolide B derivative, exhibited strong anti-inflammatory effects in vitro. In this study, we investigated its impacts on LPS-induced ARDS mice. We found that HJB-1 significantly alleviated LPS-induced pulmonary histological alterations, inflammatory cells infiltration, lung edema, as well as the generation of inflammatory cytokines TNF-α, IL-1β and IL-6 in BALF. In addition, HJB-1 markedly suppressed LPS-induced IκB-α degradation, nuclear accumulation of NF-κB p65 subunit and MAPK phosphorylation. These results suggested that HJB-1 improved LPS-induced ARDS by suppressing LPS-induced NF-κB and MAPK activation. MDPI 2016-01-11 /pmc/articles/PMC6273719/ /pubmed/26760995 http://dx.doi.org/10.3390/molecules21010077 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiaohan
Liu, Ning
Zhang, Yu-Xin
Cao, Jinjin
Wu, Donglin
Peng, Qisheng
Wang, Hong-Bing
Sun, Wan-Chun
The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title_full The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title_fullStr The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title_full_unstemmed The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title_short The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice
title_sort protective effects of hjb-1, a derivative of 17-hydroxy-jolkinolide b, on lps-induced acute distress respiratory syndrome mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273719/
https://www.ncbi.nlm.nih.gov/pubmed/26760995
http://dx.doi.org/10.3390/molecules21010077
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