Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)),...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273735/ https://www.ncbi.nlm.nih.gov/pubmed/27598114 http://dx.doi.org/10.3390/molecules21091167 |
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author | Lin, Ching-Jie Lo, I-Wen Lin, Yu-Chi Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Hwang, Tsong-Long Liou, Shorong-Shii Shen, Ya-Ching |
author_facet | Lin, Ching-Jie Lo, I-Wen Lin, Yu-Chi Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Hwang, Tsong-Long Liou, Shorong-Shii Shen, Ya-Ching |
author_sort | Lin, Ching-Jie |
collection | PubMed |
description | Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). |
format | Online Article Text |
id | pubmed-6273735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62737352018-12-28 Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya Lin, Ching-Jie Lo, I-Wen Lin, Yu-Chi Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Hwang, Tsong-Long Liou, Shorong-Shii Shen, Ya-Ching Molecules Article Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). MDPI 2016-09-02 /pmc/articles/PMC6273735/ /pubmed/27598114 http://dx.doi.org/10.3390/molecules21091167 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Ching-Jie Lo, I-Wen Lin, Yu-Chi Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Hwang, Tsong-Long Liou, Shorong-Shii Shen, Ya-Ching Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title | Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title_full | Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title_fullStr | Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title_full_unstemmed | Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title_short | Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya |
title_sort | tetranortriterpenes and limonoids from the roots of aphanamixis polystachya |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273735/ https://www.ncbi.nlm.nih.gov/pubmed/27598114 http://dx.doi.org/10.3390/molecules21091167 |
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