Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya

Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)),...

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Autores principales: Lin, Ching-Jie, Lo, I-Wen, Lin, Yu-Chi, Chen, Shun-Ying, Chien, Ching-Te, Kuo, Yao-Haur, Hwang, Tsong-Long, Liou, Shorong-Shii, Shen, Ya-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273735/
https://www.ncbi.nlm.nih.gov/pubmed/27598114
http://dx.doi.org/10.3390/molecules21091167
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author Lin, Ching-Jie
Lo, I-Wen
Lin, Yu-Chi
Chen, Shun-Ying
Chien, Ching-Te
Kuo, Yao-Haur
Hwang, Tsong-Long
Liou, Shorong-Shii
Shen, Ya-Ching
author_facet Lin, Ching-Jie
Lo, I-Wen
Lin, Yu-Chi
Chen, Shun-Ying
Chien, Ching-Te
Kuo, Yao-Haur
Hwang, Tsong-Long
Liou, Shorong-Shii
Shen, Ya-Ching
author_sort Lin, Ching-Jie
collection PubMed
description Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB).
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spelling pubmed-62737352018-12-28 Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya Lin, Ching-Jie Lo, I-Wen Lin, Yu-Chi Chen, Shun-Ying Chien, Ching-Te Kuo, Yao-Haur Hwang, Tsong-Long Liou, Shorong-Shii Shen, Ya-Ching Molecules Article Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB). MDPI 2016-09-02 /pmc/articles/PMC6273735/ /pubmed/27598114 http://dx.doi.org/10.3390/molecules21091167 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Ching-Jie
Lo, I-Wen
Lin, Yu-Chi
Chen, Shun-Ying
Chien, Ching-Te
Kuo, Yao-Haur
Hwang, Tsong-Long
Liou, Shorong-Shii
Shen, Ya-Ching
Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title_full Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title_fullStr Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title_full_unstemmed Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title_short Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya
title_sort tetranortriterpenes and limonoids from the roots of aphanamixis polystachya
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273735/
https://www.ncbi.nlm.nih.gov/pubmed/27598114
http://dx.doi.org/10.3390/molecules21091167
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