Cargando…

Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic m...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yu, Li, Da-Hong, Li, Zhan-Lin, Sun, Yan-Jun, Hua, Hui-Ming, Liu, Tao, Bai, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273775/
https://www.ncbi.nlm.nih.gov/pubmed/26729074
http://dx.doi.org/10.3390/molecules21010031
Descripción
Sumario:Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC(50) value of 4.2 μM.