Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7

Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic m...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Li, Da-Hong, Li, Zhan-Lin, Sun, Yan-Jun, Hua, Hui-Ming, Liu, Tao, Bai, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273775/
https://www.ncbi.nlm.nih.gov/pubmed/26729074
http://dx.doi.org/10.3390/molecules21010031
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author Wang, Yu
Li, Da-Hong
Li, Zhan-Lin
Sun, Yan-Jun
Hua, Hui-Ming
Liu, Tao
Bai, Jiao
author_facet Wang, Yu
Li, Da-Hong
Li, Zhan-Lin
Sun, Yan-Jun
Hua, Hui-Ming
Liu, Tao
Bai, Jiao
author_sort Wang, Yu
collection PubMed
description Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC(50) value of 4.2 μM.
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spelling pubmed-62737752018-12-28 Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7 Wang, Yu Li, Da-Hong Li, Zhan-Lin Sun, Yan-Jun Hua, Hui-Ming Liu, Tao Bai, Jiao Molecules Article Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC(50) value of 4.2 μM. MDPI 2015-12-28 /pmc/articles/PMC6273775/ /pubmed/26729074 http://dx.doi.org/10.3390/molecules21010031 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yu
Li, Da-Hong
Li, Zhan-Lin
Sun, Yan-Jun
Hua, Hui-Ming
Liu, Tao
Bai, Jiao
Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title_full Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title_fullStr Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title_full_unstemmed Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title_short Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
title_sort terpenoids from the marine-derived fungus aspergillus fumigatus yk-7
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273775/
https://www.ncbi.nlm.nih.gov/pubmed/26729074
http://dx.doi.org/10.3390/molecules21010031
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