Cargando…

Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative

The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szabó, Johanna, Jerkovics, Nóra, Schneider, Gyula, Wölfling, János, Bózsity, Noémi, Minorics, Renáta, Zupkó, István, Mernyák, Erzsébet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273777/ https://www.ncbi.nlm.nih.gov/pubmed/27187336 http://dx.doi.org/10.3390/molecules21050611

Ejemplares similares

A molecular understanding of d-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells
por: Minorics, Renáta, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates
por: Bodnár, Brigitta, et al.
Publicado: (2016)

Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives
por: Kádár, Zalán, et al.
Publicado: (2011)

Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and in vitro antiproliferative properties
por: Mernyák, Erzsébet, et al.
Publicado: (2021)

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity
por: Gyovai, András, et al.
Publicado: (2018)

A Click Approach to Novel D-Ring-Substituted 16α-Triazolylestrone Derivatives and Characterization of Their Antiproliferative Properties
por: Molnár, Judit, et al.
Publicado: (2015)

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers
por: Kovács, Édua, et al.
Publicado: (2023)

Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs †
por: Senobar Tahaei, Seyyed Ashkan, et al.
Publicado: (2023)

Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives
por: Jójárt, Rebeka, et al.
Publicado: (2020)

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors
por: Bacsa, Ildikó, et al.
Publicado: (2017)

Antiproliferative Activity of (−)‐Isopulegol‐based 1,3‐Oxazine, 1,3‐Thiazine and 2,4‐Diaminopyrimidine Derivatives
por: Bamou, Fatima Z., et al.
Publicado: (2022)

Investigation of the Antineoplastic Effects of 2-(4-Chlorophenyl)-13α-Estrone Sulfamate against the HPV16-Positive Human Invasive Cervical Carcinoma Cell Line SiHa
por: Ali, Hazhmat, et al.
Publicado: (2023)

Transition metal-catalysed A-ring C–H activations and C(sp(2))–C(sp(2)) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties
por: Traj, Péter, et al.
Publicado: (2021)

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis
por: Bacsa, Ildikó, et al.
Publicado: (2018)

The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series
por: Bacsa, Ildikó, et al.
Publicado: (2018)

Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1
por: Herman, Bianka Edina, et al.
Publicado: (2019)

Epimers of Vitamin D: A Review
por: Al-Zohily, Bashar, et al.
Publicado: (2020)

The Antioxidant and Antiproliferative Activities of 1,2,3-Triazolyl-L-Ascorbic Acid Derivatives
por: Harej, Anja, et al.
Publicado: (2019)

Anticancer and Multidrug Resistance-Reversal Effects of Solanidine Analogs Synthetized from Pregnadienolone Acetate
por: Zupkó, István, et al.
Publicado: (2014)

Synthesis and antiproliferative assay of triazolyl-2,2-dimethyl-3-phenylpropanoates as potential HDAC inhibitors
por: El-Rayes, Samir, et al.
Publicado: (2019)

Isolation, Structure Determination of Sesquiterpenes from Neurolaena lobata and Their Antiproliferative, Cell Cycle Arrest-Inducing and Anti-Invasive Properties against Human Cervical Tumor Cells
por: Vasas, Andrea, et al.
Publicado: (2021)

The total synthesis of D-chalcose and its C-3 epimer
por: Sun, Jun, et al.
Publicado: (2013)

Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors
por: Jójárt, Rebeka, et al.
Publicado: (2019)

The genetic determinants of circulating C3-epimers of 25-hydroxyvitamin D
por: Torugsa, Sirikunya, et al.
Publicado: (2018)

Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
por: He, Yi-Lin, et al.
Publicado: (2022)

Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites
por: Dávid, Csilla Zsuzsanna, et al.
Publicado: (2022)

Cinema 4D R13 Cookbook
por: Szabo, Michael
Publicado: (2012)

Synthesis and Biological Application of Isosteviol-Based 1,3-Aminoalcohols
por: Ozsvár, Dániel, et al.
Publicado: (2021)

Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpen Aminodiols
por: Ozsvár, Dániel, et al.
Publicado: (2019)

Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein
por: Chailurkit, La-or, et al.
Publicado: (2021)

Stereoselective Synthesis and Cytoselective Toxicity of Monoterpene-Fused 2-Imino-1,3-thiazines
por: Szakonyi, Zsolt, et al.
Publicado: (2014)

Site-Specific Characterization of d-Amino Acid Containing Peptide Epimers by Ion Mobility Spectrometry
por: Jia, Chenxi, et al.
Publicado: (2013)

Total synthesis of rupestine G and its epimers
por: Yusuf, Abdullah, et al.
Publicado: (2018)

Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)
por: Russo, Fabiana, et al.
Publicado: (2023)

Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors
por: Jójárt, Rebeka, et al.
Publicado: (2018)

Antimalarial Activity of C-10 Substituted Triazolyl Artemisinin
por: Park, Gab-Man, et al.
Publicado: (2017)

Click Chemistry Inspired Synthesis of Hydroxyanthracene Triazolyl Glycoconjugates
por: Pandey, Nishant, et al.
Publicado: (2022)

Misleading measures in Vitamin D analysis: A novel LC-MS/MS assay to account for epimers and isobars
por: Shah, Iltaf, et al.
Publicado: (2011)

The Road Not So Travelled: Should Measurement of Vitamin D Epimers during Pregnancy Affect Our Clinical Decisions?
por: Karras, Spyridon N., et al.
Publicado: (2017)

Stereoselective Synthesis and Antiproliferative Activities of Tetrafunctional Diterpene Steviol Derivatives
por: Bai, Dorottya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6osj9bmsfh8gpkqbjbidkd9c1k