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Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases
The central nervous system of adult mammals has long been considered as a complex static structure unable to undergo any regenerative process to refurbish its dead nodes. This dogma was challenged by Altman in the 1960s and neuron self-renewal has been demonstrated ever since in many species, includ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273783/ https://www.ncbi.nlm.nih.gov/pubmed/27598108 http://dx.doi.org/10.3390/molecules21091165 |
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author | Herrera-Arozamena, Clara Martí-Marí, Olaia Estrada, Martín de la Fuente Revenga, Mario Rodríguez-Franco, María Isabel |
author_facet | Herrera-Arozamena, Clara Martí-Marí, Olaia Estrada, Martín de la Fuente Revenga, Mario Rodríguez-Franco, María Isabel |
author_sort | Herrera-Arozamena, Clara |
collection | PubMed |
description | The central nervous system of adult mammals has long been considered as a complex static structure unable to undergo any regenerative process to refurbish its dead nodes. This dogma was challenged by Altman in the 1960s and neuron self-renewal has been demonstrated ever since in many species, including humans. Aging, neurodegenerative, and some mental diseases are associated with an exponential decrease in brain neurogenesis. Therefore, the controlled pharmacological stimulation of the endogenous neural stem cells (NSCs) niches might counteract the neuronal loss in Alzheimer’s disease (AD) and other pathologies, opening an exciting new therapeutic avenue. In the last years, druggable molecular targets and signalling pathways involved in neurogenic processes have been identified, and as a consequence, different drug types have been developed and tested in neuronal plasticity. This review focuses on recent advances in neurogenic agents acting at serotonin and/or melatonin systems, Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase (NAMPT) and nuclear erythroid 2-related factor (Nrf2). |
format | Online Article Text |
id | pubmed-6273783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62737832018-12-28 Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases Herrera-Arozamena, Clara Martí-Marí, Olaia Estrada, Martín de la Fuente Revenga, Mario Rodríguez-Franco, María Isabel Molecules Review The central nervous system of adult mammals has long been considered as a complex static structure unable to undergo any regenerative process to refurbish its dead nodes. This dogma was challenged by Altman in the 1960s and neuron self-renewal has been demonstrated ever since in many species, including humans. Aging, neurodegenerative, and some mental diseases are associated with an exponential decrease in brain neurogenesis. Therefore, the controlled pharmacological stimulation of the endogenous neural stem cells (NSCs) niches might counteract the neuronal loss in Alzheimer’s disease (AD) and other pathologies, opening an exciting new therapeutic avenue. In the last years, druggable molecular targets and signalling pathways involved in neurogenic processes have been identified, and as a consequence, different drug types have been developed and tested in neuronal plasticity. This review focuses on recent advances in neurogenic agents acting at serotonin and/or melatonin systems, Wnt/β-catenin pathway, sigma receptors, nicotinamide phosphoribosyltransferase (NAMPT) and nuclear erythroid 2-related factor (Nrf2). MDPI 2016-09-01 /pmc/articles/PMC6273783/ /pubmed/27598108 http://dx.doi.org/10.3390/molecules21091165 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Herrera-Arozamena, Clara Martí-Marí, Olaia Estrada, Martín de la Fuente Revenga, Mario Rodríguez-Franco, María Isabel Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title | Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title_full | Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title_fullStr | Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title_full_unstemmed | Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title_short | Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases |
title_sort | recent advances in neurogenic small molecules as innovative treatments for neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273783/ https://www.ncbi.nlm.nih.gov/pubmed/27598108 http://dx.doi.org/10.3390/molecules21091165 |
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