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New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges

A series of new Schiff bases were synthesized by condensation of isatins with the nalidixic acid-l-amino acid hydrazides. Prior to hydrazide formation, a peptide linkage has been prepared via coupling of nalidixic acid with appropriate l-amino acid methyl esters to yield 3a–c. The chemical structure...

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Detalles Bibliográficos
Autores principales:	Naglah, Ahmed M., Ahmed, Atallah F., Wen, Zhi-Hong, Al-Omar, Mohamed A., Amr, Abd El-Galil E., Kalmouch, Atef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273797/ https://www.ncbi.nlm.nih.gov/pubmed/27092477 http://dx.doi.org/10.3390/molecules21040498

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