Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, (1)H-NMR, (13)C-NMR, and Mass spectroscopy. Furth...

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Autores principales: El Ashry, El Sayed H., El Kilany, Yeldez, Nahas, Nariman M., Barakat, Assem, Al-Qurashi, Nadia, Ghabbour, Hazem A., Fun, Hoong-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273855/
https://www.ncbi.nlm.nih.gov/pubmed/26703551
http://dx.doi.org/10.3390/molecules21010012
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author El Ashry, El Sayed H.
El Kilany, Yeldez
Nahas, Nariman M.
Barakat, Assem
Al-Qurashi, Nadia
Ghabbour, Hazem A.
Fun, Hoong-Kun
author_facet El Ashry, El Sayed H.
El Kilany, Yeldez
Nahas, Nariman M.
Barakat, Assem
Al-Qurashi, Nadia
Ghabbour, Hazem A.
Fun, Hoong-Kun
author_sort El Ashry, El Sayed H.
collection PubMed
description Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, (1)H-NMR, (13)C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P2(1)/c, respectively.
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spelling pubmed-62738552018-12-28 Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions El Ashry, El Sayed H. El Kilany, Yeldez Nahas, Nariman M. Barakat, Assem Al-Qurashi, Nadia Ghabbour, Hazem A. Fun, Hoong-Kun Molecules Article Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, (1)H-NMR, (13)C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P2(1)/c, respectively. MDPI 2015-12-22 /pmc/articles/PMC6273855/ /pubmed/26703551 http://dx.doi.org/10.3390/molecules21010012 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El Ashry, El Sayed H.
El Kilany, Yeldez
Nahas, Nariman M.
Barakat, Assem
Al-Qurashi, Nadia
Ghabbour, Hazem A.
Fun, Hoong-Kun
Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title_full Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title_fullStr Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title_full_unstemmed Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title_short Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
title_sort synthesis and crystal structures of benzimidazole-2-thione derivatives by alkylation reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273855/
https://www.ncbi.nlm.nih.gov/pubmed/26703551
http://dx.doi.org/10.3390/molecules21010012
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