Methods for Improving Aptamer Binding Affinity

Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always obtained. Therefore, further refinement of aptamer...

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Detalles Bibliográficos
Autores principales: Hasegawa, Hijiri, Savory, Nasa, Abe, Koichi, Ikebukuro, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273865/
https://www.ncbi.nlm.nih.gov/pubmed/27043498
http://dx.doi.org/10.3390/molecules21040421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273865/
https://www.ncbi.nlm.nih.gov/pubmed/27043498
http://dx.doi.org/10.3390/molecules21040421

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