Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability

A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activ...

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Detalles Bibliográficos
Autores principales: Żołnowska, Beata, Sławiński, Jarosław, Pogorzelska, Aneta, Szafrański, Krzysztof, Kawiak, Anna, Stasiłojć, Grzegorz, Belka, Mariusz, Ulenberg, Szymon, Bączek, Tomasz, Chojnacki, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273912/
https://www.ncbi.nlm.nih.gov/pubmed/27338337
http://dx.doi.org/10.3390/molecules21060808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273912/
https://www.ncbi.nlm.nih.gov/pubmed/27338337
http://dx.doi.org/10.3390/molecules21060808

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