Synthesis and Structure-Activity Relationships of a Series of Aporphine Derivatives with Antiarrhythmic Activities and Acute Toxicity

Some aporphine alkaloids, such as crebanine, were found to present arrhythmic activity and also higher toxicity. A series of derivatives were synthesized by using three kinds of aporphine alkaloids (crebanine, isocorydine, and stephanine) as lead compounds. Chemical methods, including ring-opening r...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Cheng, Xin, Kong, Shujun, Yang, Zixian, Wang, Hongmei, Huang, Qiuyan, Li, Jingyu, Chen, Cheng, Ma, Yunshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273934/
https://www.ncbi.nlm.nih.gov/pubmed/27916812
http://dx.doi.org/10.3390/molecules21121555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273934/
https://www.ncbi.nlm.nih.gov/pubmed/27916812
http://dx.doi.org/10.3390/molecules21121555

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