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Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leuk...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273944/ https://www.ncbi.nlm.nih.gov/pubmed/27144551 http://dx.doi.org/10.3390/molecules21050579 |
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author | Onnis, Valentina Demurtas, Monica Deplano, Alessandro Balboni, Gianfranco Baldisserotto, Anna Manfredini, Stefano Pacifico, Salvatore Liekens, Sandra Balzarini, Jan |
author_facet | Onnis, Valentina Demurtas, Monica Deplano, Alessandro Balboni, Gianfranco Baldisserotto, Anna Manfredini, Stefano Pacifico, Salvatore Liekens, Sandra Balzarini, Jan |
author_sort | Onnis, Valentina |
collection | PubMed |
description | The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC(50) values in the low micromolar range. |
format | Online Article Text |
id | pubmed-6273944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62739442018-12-28 Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones Onnis, Valentina Demurtas, Monica Deplano, Alessandro Balboni, Gianfranco Baldisserotto, Anna Manfredini, Stefano Pacifico, Salvatore Liekens, Sandra Balzarini, Jan Molecules Article The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC(50) values in the low micromolar range. MDPI 2016-04-30 /pmc/articles/PMC6273944/ /pubmed/27144551 http://dx.doi.org/10.3390/molecules21050579 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Onnis, Valentina Demurtas, Monica Deplano, Alessandro Balboni, Gianfranco Baldisserotto, Anna Manfredini, Stefano Pacifico, Salvatore Liekens, Sandra Balzarini, Jan Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title | Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title_full | Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title_fullStr | Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title_full_unstemmed | Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title_short | Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones |
title_sort | design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273944/ https://www.ncbi.nlm.nih.gov/pubmed/27144551 http://dx.doi.org/10.3390/molecules21050579 |
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