Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel

A heterogeneous supramolecular catalytic system for multicomponent aldol-‘click’ reactions is reported. The copper(I) metallohydrogel functionalized with a phenyltriazole fragment was able to catalyze the multicomponent reaction between phenylacetylene, p-nitrobenzaldehyde, and an azide containing a...

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Autores principales: Araújo, Marco, Muñoz Capdevila, Iván, Díaz-Oltra, Santiago, Escuder, Beatriu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273958/
https://www.ncbi.nlm.nih.gov/pubmed/27338313
http://dx.doi.org/10.3390/molecules21060744
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author Araújo, Marco
Muñoz Capdevila, Iván
Díaz-Oltra, Santiago
Escuder, Beatriu
author_facet Araújo, Marco
Muñoz Capdevila, Iván
Díaz-Oltra, Santiago
Escuder, Beatriu
author_sort Araújo, Marco
collection PubMed
description A heterogeneous supramolecular catalytic system for multicomponent aldol-‘click’ reactions is reported. The copper(I) metallohydrogel functionalized with a phenyltriazole fragment was able to catalyze the multicomponent reaction between phenylacetylene, p-nitrobenzaldehyde, and an azide containing a ketone moiety, obtaining the corresponding aldol products in good yields. A possible mechanistic pathway responsible for this unexpected catalytic behavior has been proposed.
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spelling pubmed-62739582018-12-28 Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel Araújo, Marco Muñoz Capdevila, Iván Díaz-Oltra, Santiago Escuder, Beatriu Molecules Article A heterogeneous supramolecular catalytic system for multicomponent aldol-‘click’ reactions is reported. The copper(I) metallohydrogel functionalized with a phenyltriazole fragment was able to catalyze the multicomponent reaction between phenylacetylene, p-nitrobenzaldehyde, and an azide containing a ketone moiety, obtaining the corresponding aldol products in good yields. A possible mechanistic pathway responsible for this unexpected catalytic behavior has been proposed. MDPI 2016-06-08 /pmc/articles/PMC6273958/ /pubmed/27338313 http://dx.doi.org/10.3390/molecules21060744 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Araújo, Marco
Muñoz Capdevila, Iván
Díaz-Oltra, Santiago
Escuder, Beatriu
Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title_full Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title_fullStr Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title_full_unstemmed Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title_short Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular Hydrogel
title_sort tandem catalysis of an aldol-‘click’ reaction system within a molecular hydrogel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273958/
https://www.ncbi.nlm.nih.gov/pubmed/27338313
http://dx.doi.org/10.3390/molecules21060744
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