Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols

The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the...

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Autores principales: Fers-Lidou, Anthony, Berger, Olivier, Montchamp, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273960/
https://www.ncbi.nlm.nih.gov/pubmed/27689979
http://dx.doi.org/10.3390/molecules21101295
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author Fers-Lidou, Anthony
Berger, Olivier
Montchamp, Jean-Luc
author_facet Fers-Lidou, Anthony
Berger, Olivier
Montchamp, Jean-Luc
author_sort Fers-Lidou, Anthony
collection PubMed
description The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R(1)R(2)P(O)H.
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spelling pubmed-62739602018-12-28 Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols Fers-Lidou, Anthony Berger, Olivier Montchamp, Jean-Luc Molecules Article The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R(1)R(2)P(O)H. MDPI 2016-09-28 /pmc/articles/PMC6273960/ /pubmed/27689979 http://dx.doi.org/10.3390/molecules21101295 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fers-Lidou, Anthony
Berger, Olivier
Montchamp, Jean-Luc
Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title_full Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title_fullStr Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title_full_unstemmed Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title_short Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols
title_sort palladium-catalyzed allylation/benzylation of h-phosphinate esters with alcohols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273960/
https://www.ncbi.nlm.nih.gov/pubmed/27689979
http://dx.doi.org/10.3390/molecules21101295
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AT montchampjeanluc palladiumcatalyzedallylationbenzylationofhphosphinateesterswithalcohols

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