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Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker

There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureu...

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Detalles Bibliográficos
Autores principales: Shuai, Cijun, Zhou, Jianhua, Gao, Dan, Gao, Chengde, Feng, Pei, Peng, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273971/
https://www.ncbi.nlm.nih.gov/pubmed/26999100
http://dx.doi.org/10.3390/molecules21030378
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author Shuai, Cijun
Zhou, Jianhua
Gao, Dan
Gao, Chengde
Feng, Pei
Peng, Shuping
author_facet Shuai, Cijun
Zhou, Jianhua
Gao, Dan
Gao, Chengde
Feng, Pei
Peng, Shuping
author_sort Shuai, Cijun
collection PubMed
description There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility.
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spelling pubmed-62739712018-12-28 Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker Shuai, Cijun Zhou, Jianhua Gao, Dan Gao, Chengde Feng, Pei Peng, Shuping Molecules Article There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility. MDPI 2016-03-18 /pmc/articles/PMC6273971/ /pubmed/26999100 http://dx.doi.org/10.3390/molecules21030378 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shuai, Cijun
Zhou, Jianhua
Gao, Dan
Gao, Chengde
Feng, Pei
Peng, Shuping
Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title_full Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title_fullStr Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title_full_unstemmed Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title_short Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker
title_sort functionalization of calcium sulfate/bioglass scaffolds with zinc oxide whisker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273971/
https://www.ncbi.nlm.nih.gov/pubmed/26999100
http://dx.doi.org/10.3390/molecules21030378
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