Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals

Protease inhibitors are key components in the chemotherapy of HIV infection. However, the appearance of viral mutants routinely compromises their clinical efficacy, creating a constant need for new and more potent inhibitors. Recently, a new class of epoxide-based inhibitors of HIV-1 protease was in...

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Detalles Bibliográficos
Autores principales: Olajuyigbe, Folasade M., Demitri, Nicola, De Zorzi, Rita, Geremia, Silvano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273989/
https://www.ncbi.nlm.nih.gov/pubmed/27809253
http://dx.doi.org/10.3390/molecules21111458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273989/
https://www.ncbi.nlm.nih.gov/pubmed/27809253
http://dx.doi.org/10.3390/molecules21111458

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