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Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals
Protease inhibitors are key components in the chemotherapy of HIV infection. However, the appearance of viral mutants routinely compromises their clinical efficacy, creating a constant need for new and more potent inhibitors. Recently, a new class of epoxide-based inhibitors of HIV-1 protease was in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273989/ https://www.ncbi.nlm.nih.gov/pubmed/27809253 http://dx.doi.org/10.3390/molecules21111458 |