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Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities
One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were esta...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273999/ https://www.ncbi.nlm.nih.gov/pubmed/27827998 http://dx.doi.org/10.3390/molecules21111481 |
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author | Li, Jinjie Zhang, Bo Liu, Hailing Zhang, Xuan Shang, Xiaoya Zhao, Changqi |
author_facet | Li, Jinjie Zhang, Bo Liu, Hailing Zhang, Xuan Shang, Xiaoya Zhao, Changqi |
author_sort | Li, Jinjie |
collection | PubMed |
description | One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC(50) values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65. |
format | Online Article Text |
id | pubmed-6273999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62739992018-12-28 Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities Li, Jinjie Zhang, Bo Liu, Hailing Zhang, Xuan Shang, Xiaoya Zhao, Changqi Molecules Article One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC(50) values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65. MDPI 2016-11-07 /pmc/articles/PMC6273999/ /pubmed/27827998 http://dx.doi.org/10.3390/molecules21111481 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Jinjie Zhang, Bo Liu, Hailing Zhang, Xuan Shang, Xiaoya Zhao, Changqi Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title | Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title_full | Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title_fullStr | Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title_full_unstemmed | Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title_short | Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities |
title_sort | triterpenoids from ainsliaea yunnanensis franch. and their biological activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273999/ https://www.ncbi.nlm.nih.gov/pubmed/27827998 http://dx.doi.org/10.3390/molecules21111481 |
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