A Versatile Axle for the Construction of Disassemblage Rotaxanes

Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC and (1)H-NMR analysis. The axle is highly charged, w...

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Detalles Bibliográficos
Autores principales: Powers, Lucas A., Smithrud, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274001/
https://www.ncbi.nlm.nih.gov/pubmed/27517897
http://dx.doi.org/10.3390/molecules21081043
Descripción
Sumario:Rotaxanes are unique mechanical devices that hold great promise as sensors. We report on two new rotaxanes that contain an acid or base sensitive trigger and readily disassemble in a wide range of environments. Disassemblage was observed under TLC and (1)H-NMR analysis. The axle is highly charged, which enhances solubility in aqueous environments, and can be readily derivatized with sensor components. The trigger was swapped in a one-pot method, which is promising for the rapid production of a series of sensors.

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