Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2

Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracel...

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Detalles Bibliográficos
Autores principales: Wang, Liyan, Wu, Yanhua, Chen, Yongtao, Zou, Jiaxin, Li, Xiaofan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274042/
https://www.ncbi.nlm.nih.gov/pubmed/27399656
http://dx.doi.org/10.3390/molecules21070883
Descripción
Sumario:Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC(50) = 161.4 μM) compared with resveratrol (IC(50) = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC(50) = 78.6 μM and 87.9 μM).

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