Cargando…
Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracel...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274042/ https://www.ncbi.nlm.nih.gov/pubmed/27399656 http://dx.doi.org/10.3390/molecules21070883 |
_version_ | 1783377527053484032 |
---|---|
author | Wang, Liyan Wu, Yanhua Chen, Yongtao Zou, Jiaxin Li, Xiaofan |
author_facet | Wang, Liyan Wu, Yanhua Chen, Yongtao Zou, Jiaxin Li, Xiaofan |
author_sort | Wang, Liyan |
collection | PubMed |
description | Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC(50) = 161.4 μM) compared with resveratrol (IC(50) = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC(50) = 78.6 μM and 87.9 μM). |
format | Online Article Text |
id | pubmed-6274042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62740422018-12-28 Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 Wang, Liyan Wu, Yanhua Chen, Yongtao Zou, Jiaxin Li, Xiaofan Molecules Article Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC(50) = 161.4 μM) compared with resveratrol (IC(50) = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC(50) = 78.6 μM and 87.9 μM). MDPI 2016-07-06 /pmc/articles/PMC6274042/ /pubmed/27399656 http://dx.doi.org/10.3390/molecules21070883 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Liyan Wu, Yanhua Chen, Yongtao Zou, Jiaxin Li, Xiaofan Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title | Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title_full | Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title_fullStr | Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title_full_unstemmed | Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title_short | Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2 |
title_sort | biotransformation of resveratrol: new prenylated trans-resveratrol synthesized by aspergillus sp. scsiow2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274042/ https://www.ncbi.nlm.nih.gov/pubmed/27399656 http://dx.doi.org/10.3390/molecules21070883 |
work_keys_str_mv | AT wangliyan biotransformationofresveratrolnewprenylatedtransresveratrolsynthesizedbyaspergillusspscsiow2 AT wuyanhua biotransformationofresveratrolnewprenylatedtransresveratrolsynthesizedbyaspergillusspscsiow2 AT chenyongtao biotransformationofresveratrolnewprenylatedtransresveratrolsynthesizedbyaspergillusspscsiow2 AT zoujiaxin biotransformationofresveratrolnewprenylatedtransresveratrolsynthesizedbyaspergillusspscsiow2 AT lixiaofan biotransformationofresveratrolnewprenylatedtransresveratrolsynthesizedbyaspergillusspscsiow2 |