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Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives

Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency; milling balls weight and milling time. The optimum reaction condition was milling with 56.6 g weight of balls at 20 Hz f...

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Autores principales: EL-Sayed, Taghreed H., Aboelnaga, Asmaa, Hagar, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274055/
https://www.ncbi.nlm.nih.gov/pubmed/27563861
http://dx.doi.org/10.3390/molecules21091111
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author EL-Sayed, Taghreed H.
Aboelnaga, Asmaa
Hagar, Mohamed
author_facet EL-Sayed, Taghreed H.
Aboelnaga, Asmaa
Hagar, Mohamed
author_sort EL-Sayed, Taghreed H.
collection PubMed
description Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency; milling balls weight and milling time. The optimum reaction condition was milling with 56.6 g weight of balls at 20 Hz frequency for one hour milling time. The study was extended for synthesis of a series of benzimidazol-2-one or benzimidazol-2-thione using different aldehydes; carboxylic acids; urea; thiourea or ammonium thiocyanate with o-phenylenediamine. Moreover; the alkylation of benzimidazolone or benzimidazolthione using ethyl chloroacetate was also studied.
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spelling pubmed-62740552018-12-28 Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives EL-Sayed, Taghreed H. Aboelnaga, Asmaa Hagar, Mohamed Molecules Article Benzoic acid and o-phenylenediamine efficiently reacted under the green solvent-free Ball Milling method. Several reaction parameters were investigated such as rotation frequency; milling balls weight and milling time. The optimum reaction condition was milling with 56.6 g weight of balls at 20 Hz frequency for one hour milling time. The study was extended for synthesis of a series of benzimidazol-2-one or benzimidazol-2-thione using different aldehydes; carboxylic acids; urea; thiourea or ammonium thiocyanate with o-phenylenediamine. Moreover; the alkylation of benzimidazolone or benzimidazolthione using ethyl chloroacetate was also studied. MDPI 2016-08-24 /pmc/articles/PMC6274055/ /pubmed/27563861 http://dx.doi.org/10.3390/molecules21091111 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
EL-Sayed, Taghreed H.
Aboelnaga, Asmaa
Hagar, Mohamed
Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title_full Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title_fullStr Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title_full_unstemmed Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title_short Ball Milling Assisted Solvent and Catalyst Free Synthesis of Benzimidazoles and Their Derivatives
title_sort ball milling assisted solvent and catalyst free synthesis of benzimidazoles and their derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274055/
https://www.ncbi.nlm.nih.gov/pubmed/27563861
http://dx.doi.org/10.3390/molecules21091111
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