Cargando…

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties. In the present study, a conjugated 2,4-dioxo-pyrimidine-1-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Yan, Zhang, Yang, Li, Yuhang, Ren, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274076/ https://www.ncbi.nlm.nih.gov/pubmed/26901181 http://dx.doi.org/10.3390/molecules21020229

Ejemplares similares

Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase
por: Kiss, László E., et al.
Publicado: (2018)

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
por: Deplano, Alessandro, et al.
Publicado: (2019)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018)

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
por: Sunduru, Naresh, et al.
Publicado: (2017)

The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition
por: Palermo, Giulia, et al.
Publicado: (2015)

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors
por: Criscuolo, Emanuele, et al.
Publicado: (2020)

Para-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, Synthesis and Biological Evaluation
por: Sedaghat, Anna, et al.
Publicado: (2020)

Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
por: Deplano, Alessandro, et al.
Publicado: (2020)

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015)

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding
por: Sekiba, Kazuma, et al.
Publicado: (2020)

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474
por: Bonifácio, Maria‐João, et al.
Publicado: (2020)

Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
por: D'Addario, Claudio, et al.
Publicado: (2012)

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study
por: Björklund, Emmelie, et al.
Publicado: (2014)

Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators
por: Tripathi, Neetika, et al.
Publicado: (2018)

A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain
por: Benson, N, et al.
Publicado: (2014)

Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats
por: Zubrzycki, Marek, et al.
Publicado: (2022)

Discovery of New Uracil and Thiouracil Derivatives as Potential HDAC Inhibitors
por: Elbatrawy, Omnia R., et al.
Publicado: (2023)

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity
por: Mofford, David M., et al.
Publicado: (2015)

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro
por: Dongdem, Julius T., et al.
Publicado: (2022)

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase
por: Sabatucci, Annalaura, et al.
Publicado: (2019)

Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells
por: Winkler, Katrin, et al.
Publicado: (2016)

Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice
por: Kruk-Slomka, Marta, et al.
Publicado: (2019)

Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides
por: Arias-Gaguancela, Omar, et al.
Publicado: (2023)

Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases
por: Qi, Huitang, et al.
Publicado: (2021)

Cellular viability effects of fatty acid amide hydrolase inhibition on cerebellar neurons
por: Lueneberg, Kathia, et al.
Publicado: (2011)

Overexpression of Fatty Acid Amide Hydrolase Induces Early Flowering in Arabidopsis thaliana
por: Teaster, Neal D., et al.
Publicado: (2012)

Inhibition of Vascular Growth by Modulation of the Anandamide/Fatty Acid Amide Hydrolase Axis
por: Rieck, Sarah, et al.
Publicado: (2021)

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer
por: Tundidor, Isabel, et al.
Publicado: (2023)

The Roles of Anandamide, Fatty Acid Amide Hydrolase, and Leukemia Inhibitory Factor on the Endometrium during the Implantation Window
por: Cui, Na, et al.
Publicado: (2017)

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety
por: Carnevali, Luca, et al.
Publicado: (2015)

Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors
por: Khan, Imran Ahmad, et al.
Publicado: (2021)

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice
por: Cassano, Tommaso, et al.
Publicado: (2010)

Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
por: Sirrs, Sandra, et al.
Publicado: (2015)

PET Imaging of Fatty Acid Amide Hydrolase with [(18)F]DOPP in Nonhuman Primates
por: Rotstein, Benjamin H., et al.
Publicado: (2014)

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
por: Carey, Lawrence M, et al.
Publicado: (2016)

Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation
por: Green, Duncan GJ., et al.
Publicado: (2022)

Acute Administration of URB597 Fatty Acid Amide Hydrolase Inhibitor Prevents Attentional Impairments by Distractors in Adolescent Mice
por: Contarini, Gabriella, et al.
Publicado: (2019)

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors
por: Brotherton-Pleiss, Christine, et al.
Publicado: (2020)

Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain
por: Du, Fangyu, et al.
Publicado: (2022)

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats
por: Vinod, K. Yaragudri, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_b44tokbpkmjp56d6ol4rna7u9g