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Exploiting the Biosynthetic Potential of Type III Polyketide Synthases
Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies in the engineering and structural characterization of PKSs have facilitated the use of target enzymes as biocatalysts to produc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274091/ https://www.ncbi.nlm.nih.gov/pubmed/27338328 http://dx.doi.org/10.3390/molecules21060806 |
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author | Lim, Yan Ping Go, Maybelle K. Yew, Wen Shan |
author_facet | Lim, Yan Ping Go, Maybelle K. Yew, Wen Shan |
author_sort | Lim, Yan Ping |
collection | PubMed |
description | Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies in the engineering and structural characterization of PKSs have facilitated the use of target enzymes as biocatalysts to produce novel functionally optimized polyketides. These compounds may serve as potential drug leads. This review summarizes the insights gained from research on type III PKSs, from the discovery of chalcone synthase in plants to novel PKSs in bacteria and fungi. To date, at least 15 families of type III PKSs have been characterized, highlighting the utility of PKSs in the development of natural product libraries for therapeutic development. |
format | Online Article Text |
id | pubmed-6274091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62740912018-12-28 Exploiting the Biosynthetic Potential of Type III Polyketide Synthases Lim, Yan Ping Go, Maybelle K. Yew, Wen Shan Molecules Review Polyketides are structurally and functionally diverse secondary metabolites that are biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies in the engineering and structural characterization of PKSs have facilitated the use of target enzymes as biocatalysts to produce novel functionally optimized polyketides. These compounds may serve as potential drug leads. This review summarizes the insights gained from research on type III PKSs, from the discovery of chalcone synthase in plants to novel PKSs in bacteria and fungi. To date, at least 15 families of type III PKSs have been characterized, highlighting the utility of PKSs in the development of natural product libraries for therapeutic development. MDPI 2016-06-22 /pmc/articles/PMC6274091/ /pubmed/27338328 http://dx.doi.org/10.3390/molecules21060806 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lim, Yan Ping Go, Maybelle K. Yew, Wen Shan Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title | Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title_full | Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title_fullStr | Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title_full_unstemmed | Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title_short | Exploiting the Biosynthetic Potential of Type III Polyketide Synthases |
title_sort | exploiting the biosynthetic potential of type iii polyketide synthases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274091/ https://www.ncbi.nlm.nih.gov/pubmed/27338328 http://dx.doi.org/10.3390/molecules21060806 |
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