Two New Clerodane Diterpenes from Tinospora sagittata

Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spect...

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Detalles Bibliográficos
Autores principales: Li, Guanhua, Ding, Wenbing, Wan, Fanghao, Li, Youzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274121/
https://www.ncbi.nlm.nih.gov/pubmed/27657021
http://dx.doi.org/10.3390/molecules21091250
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author Li, Guanhua
Ding, Wenbing
Wan, Fanghao
Li, Youzhi
author_facet Li, Guanhua
Ding, Wenbing
Wan, Fanghao
Li, Youzhi
author_sort Li, Guanhua
collection PubMed
description Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro.
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spelling pubmed-62741212018-12-28 Two New Clerodane Diterpenes from Tinospora sagittata Li, Guanhua Ding, Wenbing Wan, Fanghao Li, Youzhi Molecules Communication Two new clerodane-type diterpenes, tinosporins C (1) and tinosporins D (2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin (3), tinophylloloside (4), and tinospinoside D (5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro. MDPI 2016-09-19 /pmc/articles/PMC6274121/ /pubmed/27657021 http://dx.doi.org/10.3390/molecules21091250 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Guanhua
Ding, Wenbing
Wan, Fanghao
Li, Youzhi
Two New Clerodane Diterpenes from Tinospora sagittata
title Two New Clerodane Diterpenes from Tinospora sagittata
title_full Two New Clerodane Diterpenes from Tinospora sagittata
title_fullStr Two New Clerodane Diterpenes from Tinospora sagittata
title_full_unstemmed Two New Clerodane Diterpenes from Tinospora sagittata
title_short Two New Clerodane Diterpenes from Tinospora sagittata
title_sort two new clerodane diterpenes from tinospora sagittata
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274121/
https://www.ncbi.nlm.nih.gov/pubmed/27657021
http://dx.doi.org/10.3390/molecules21091250
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AT wanfanghao twonewclerodanediterpenesfromtinosporasagittata
AT liyouzhi twonewclerodanediterpenesfromtinosporasagittata

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