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Molecular Encapsulation of Histamine H(2)-Receptor Antagonists by Cucurbit[7]Uril: An Experimental and Computational Study
The histamine H(2)-receptor antagonists cimetidine, famotidine and nizatidine are individually encapsulated by macrocyclic cucurbit[7]uril (CB[7]), with binding affinities of 6.57 (±0.19) × 10(3) M(−1), 1.30 (±0.27) × 10(4) M(−1) and 1.05 (±0.33) × 10(5) M(−1), respectively. These 1:1 host-guest inc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274153/ https://www.ncbi.nlm.nih.gov/pubmed/27608003 http://dx.doi.org/10.3390/molecules21091178 |