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Antiproliferative Effect of Indole Phytoalexins

Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Mos...

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Autores principales: Chripkova, Martina, Zigo, Frantisek, Mojzis, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274154/
https://www.ncbi.nlm.nih.gov/pubmed/27898039
http://dx.doi.org/10.3390/molecules21121626
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author Chripkova, Martina
Zigo, Frantisek
Mojzis, Jan
author_facet Chripkova, Martina
Zigo, Frantisek
Mojzis, Jan
author_sort Chripkova, Martina
collection PubMed
description Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities.
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spelling pubmed-62741542018-12-28 Antiproliferative Effect of Indole Phytoalexins Chripkova, Martina Zigo, Frantisek Mojzis, Jan Molecules Review Indole phytoalexins from crucifers have been shown to exhibit significant anti-cancer, chemopreventive, and antiproliferative activity. Phytoalexins are natural low molecular antimicrobial compounds that are synthesized and accumulated in plants after their exposure to pathogenic microorganisms. Most interestingly, crucifers appear to be the only plant family producing sulfur-containing indole phytoalexins. The mechanisms underlying its anti-cancer properties are unknown. Isolation from cruciferous plants does not provide sufficient quantities of indole phytoalexins and, for biological screening, they are usually obtainable through synthesis. Understanding the molecular mechanism of the action of these substances and their structure-activity relationships is quite important in the development of new analogs with a more favorable profile of biological activities. In this review, we present the key features of indole phytoalexins, mainly their antiproliferative ativities. MDPI 2016-11-26 /pmc/articles/PMC6274154/ /pubmed/27898039 http://dx.doi.org/10.3390/molecules21121626 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chripkova, Martina
Zigo, Frantisek
Mojzis, Jan
Antiproliferative Effect of Indole Phytoalexins
title Antiproliferative Effect of Indole Phytoalexins
title_full Antiproliferative Effect of Indole Phytoalexins
title_fullStr Antiproliferative Effect of Indole Phytoalexins
title_full_unstemmed Antiproliferative Effect of Indole Phytoalexins
title_short Antiproliferative Effect of Indole Phytoalexins
title_sort antiproliferative effect of indole phytoalexins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274154/
https://www.ncbi.nlm.nih.gov/pubmed/27898039
http://dx.doi.org/10.3390/molecules21121626
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