Cargando…

Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the r...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yoon Hee, Jin, Bora, Lee, Sung Hyun, Song, MiKyung, Bae, HyeonHui, Min, Byung Jae, Park, Juyeon, Lee, Donghun, Kim, Hocheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274173/
https://www.ncbi.nlm.nih.gov/pubmed/27792149
http://dx.doi.org/10.3390/molecules21111424
_version_ 1783377557571239936
author Lee, Yoon Hee
Jin, Bora
Lee, Sung Hyun
Song, MiKyung
Bae, HyeonHui
Min, Byung Jae
Park, Juyeon
Lee, Donghun
Kim, Hocheol
author_facet Lee, Yoon Hee
Jin, Bora
Lee, Sung Hyun
Song, MiKyung
Bae, HyeonHui
Min, Byung Jae
Park, Juyeon
Lee, Donghun
Kim, Hocheol
author_sort Lee, Yoon Hee
collection PubMed
description It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats. We fed rats with five different diets for 10 weeks: chow diet (STD), high-fat diet (HFD), high-fat diet with 0.04% orlistat, a drug to treat obesity (HFD + Orlistat), high-fat diet with 0.2% HT048 (w/w; HFD + 0.2% HT048), and high-fat diet with 0.6% HT048 (w/w; HFD + 0.6% HT048). It was found that both body and total white adipose tissue weight of HT048 groups significantly decreased compared to those of the HFD group. Moreover, HT048 decreased serum insulin levels in HFD-fed obese rats. At the molecular level, HT048 supplementation downregulated genes involved in lipogenesis, gluconeogenesis, and adipogenesis, while the expression level of β-oxidation genes was increased. Supplementation-drug interactions are not likely as HFD and HT048-containing diet did not significantly induce genes encoding CYPs. Collectively, this study suggests that HT048 taken as dietary supplement helps to decrease obesity and insulin resistance in HFD-fed obese rats.
format Online
Article
Text
id pubmed-6274173
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62741732018-12-28 Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats Lee, Yoon Hee Jin, Bora Lee, Sung Hyun Song, MiKyung Bae, HyeonHui Min, Byung Jae Park, Juyeon Lee, Donghun Kim, Hocheol Molecules Article It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats. We fed rats with five different diets for 10 weeks: chow diet (STD), high-fat diet (HFD), high-fat diet with 0.04% orlistat, a drug to treat obesity (HFD + Orlistat), high-fat diet with 0.2% HT048 (w/w; HFD + 0.2% HT048), and high-fat diet with 0.6% HT048 (w/w; HFD + 0.6% HT048). It was found that both body and total white adipose tissue weight of HT048 groups significantly decreased compared to those of the HFD group. Moreover, HT048 decreased serum insulin levels in HFD-fed obese rats. At the molecular level, HT048 supplementation downregulated genes involved in lipogenesis, gluconeogenesis, and adipogenesis, while the expression level of β-oxidation genes was increased. Supplementation-drug interactions are not likely as HFD and HT048-containing diet did not significantly induce genes encoding CYPs. Collectively, this study suggests that HT048 taken as dietary supplement helps to decrease obesity and insulin resistance in HFD-fed obese rats. MDPI 2016-10-25 /pmc/articles/PMC6274173/ /pubmed/27792149 http://dx.doi.org/10.3390/molecules21111424 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yoon Hee
Jin, Bora
Lee, Sung Hyun
Song, MiKyung
Bae, HyeonHui
Min, Byung Jae
Park, Juyeon
Lee, Donghun
Kim, Hocheol
Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title_full Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title_fullStr Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title_full_unstemmed Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title_short Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
title_sort herbal formula ht048 attenuates diet-induced obesity by improving hepatic lipid metabolism and insulin resistance in obese rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274173/
https://www.ncbi.nlm.nih.gov/pubmed/27792149
http://dx.doi.org/10.3390/molecules21111424
work_keys_str_mv AT leeyoonhee herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT jinbora herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT leesunghyun herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT songmikyung herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT baehyeonhui herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT minbyungjae herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT parkjuyeon herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT leedonghun herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats
AT kimhocheol herbalformulaht048attenuatesdietinducedobesitybyimprovinghepaticlipidmetabolismandinsulinresistanceinobeserats