Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides

A series of C(2)-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording c...

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Detalles Bibliográficos
Autores principales: He, Weiping, Zhao, Wei, Zhou, Bihui, Liu, Haifeng, Li, Xiangrong, Li, Linlin, Li, Jie, Shi, Jianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274209/
https://www.ncbi.nlm.nih.gov/pubmed/27338322
http://dx.doi.org/10.3390/molecules21060742
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author He, Weiping
Zhao, Wei
Zhou, Bihui
Liu, Haifeng
Li, Xiangrong
Li, Linlin
Li, Jie
Shi, Jianyou
author_facet He, Weiping
Zhao, Wei
Zhou, Bihui
Liu, Haifeng
Li, Xiangrong
Li, Linlin
Li, Jie
Shi, Jianyou
author_sort He, Weiping
collection PubMed
description A series of C(2)-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities.
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spelling pubmed-62742092018-12-28 Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides He, Weiping Zhao, Wei Zhou, Bihui Liu, Haifeng Li, Xiangrong Li, Linlin Li, Jie Shi, Jianyou Molecules Communication A series of C(2)-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities. MDPI 2016-06-08 /pmc/articles/PMC6274209/ /pubmed/27338322 http://dx.doi.org/10.3390/molecules21060742 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
He, Weiping
Zhao, Wei
Zhou, Bihui
Liu, Haifeng
Li, Xiangrong
Li, Linlin
Li, Jie
Shi, Jianyou
Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title_full Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title_fullStr Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title_full_unstemmed Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title_short Synthesis of C(2)-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
title_sort synthesis of c(2)-symmetric benzimidazolium salts and their application in palladium-catalyzed enantioselective intramolecular α-arylation of amides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274209/
https://www.ncbi.nlm.nih.gov/pubmed/27338322
http://dx.doi.org/10.3390/molecules21060742
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