Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides

Based on a common structural core of 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridine, a number of bicyclic triazolium ionic liquids 1–3 were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids 1 and 2 requires no chromatographic separation. Also in this work,...

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Detalles Bibliográficos
Autores principales: Li, Hsin-Yi, Chen, Chien-Yuan, Cheng, Hui-Ting, Chu, Yen-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274210/
https://www.ncbi.nlm.nih.gov/pubmed/27754392
http://dx.doi.org/10.3390/molecules21101355
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author Li, Hsin-Yi
Chen, Chien-Yuan
Cheng, Hui-Ting
Chu, Yen-Ho
author_facet Li, Hsin-Yi
Chen, Chien-Yuan
Cheng, Hui-Ting
Chu, Yen-Ho
author_sort Li, Hsin-Yi
collection PubMed
description Based on a common structural core of 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridine, a number of bicyclic triazolium ionic liquids 1–3 were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids 1 and 2 requires no chromatographic separation. Also in this work, ionic liquids 1, 2 were shown to be efficient ionic solvents for fast synthesis of tryptanthrin natural product. Furthermore, a new affinity ionic liquid 3 was tailor-synthesized and displayed its effectiveness in chemoselective extraction of both Cu(II) ions and, for the first time, histidine-containing peptides.
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spelling pubmed-62742102018-12-28 Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides Li, Hsin-Yi Chen, Chien-Yuan Cheng, Hui-Ting Chu, Yen-Ho Molecules Communication Based on a common structural core of 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridine, a number of bicyclic triazolium ionic liquids 1–3 were designed and successfully prepared. In our hands, this optimized synthesis of ionic liquids 1 and 2 requires no chromatographic separation. Also in this work, ionic liquids 1, 2 were shown to be efficient ionic solvents for fast synthesis of tryptanthrin natural product. Furthermore, a new affinity ionic liquid 3 was tailor-synthesized and displayed its effectiveness in chemoselective extraction of both Cu(II) ions and, for the first time, histidine-containing peptides. MDPI 2016-10-13 /pmc/articles/PMC6274210/ /pubmed/27754392 http://dx.doi.org/10.3390/molecules21101355 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Hsin-Yi
Chen, Chien-Yuan
Cheng, Hui-Ting
Chu, Yen-Ho
Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title_full Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title_fullStr Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title_full_unstemmed Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title_short Exploiting 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ions and Histidine-Containing Peptides
title_sort exploiting 1,2,3-triazolium ionic liquids for synthesis of tryptanthrin and chemoselective extraction of copper(ii) ions and histidine-containing peptides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274210/
https://www.ncbi.nlm.nih.gov/pubmed/27754392
http://dx.doi.org/10.3390/molecules21101355
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