Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes

In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by...

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Autores principales: Habala, Ladislav, Varényi, Samuel, Bilková, Andrea, Herich, Peter, Valentová, Jindra, Kožíšek, Jozef, Devínsky, Ferdinand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274214/
https://www.ncbi.nlm.nih.gov/pubmed/27999327
http://dx.doi.org/10.3390/molecules21121742
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author Habala, Ladislav
Varényi, Samuel
Bilková, Andrea
Herich, Peter
Valentová, Jindra
Kožíšek, Jozef
Devínsky, Ferdinand
author_facet Habala, Ladislav
Varényi, Samuel
Bilková, Andrea
Herich, Peter
Valentová, Jindra
Kožíšek, Jozef
Devínsky, Ferdinand
author_sort Habala, Ladislav
collection PubMed
description In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II) complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid.
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spelling pubmed-62742142018-12-28 Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes Habala, Ladislav Varényi, Samuel Bilková, Andrea Herich, Peter Valentová, Jindra Kožíšek, Jozef Devínsky, Ferdinand Molecules Article In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II) complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid. MDPI 2016-12-17 /pmc/articles/PMC6274214/ /pubmed/27999327 http://dx.doi.org/10.3390/molecules21121742 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Habala, Ladislav
Varényi, Samuel
Bilková, Andrea
Herich, Peter
Valentová, Jindra
Kožíšek, Jozef
Devínsky, Ferdinand
Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title_full Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title_fullStr Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title_full_unstemmed Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title_short Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes
title_sort antimicrobial activity and urease inhibition of schiff bases derived from isoniazid and fluorinated benzaldehydes and of their copper(ii) complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274214/
https://www.ncbi.nlm.nih.gov/pubmed/27999327
http://dx.doi.org/10.3390/molecules21121742
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