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New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in...

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Autores principales: Law, Betty Yuen Kwan, Mok, Simon Wing Fai, Wu, An Guo, Lam, Christopher Wai Kei, Yu, Margaret Xin Yi, Wong, Vincent Kam Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274228/
https://www.ncbi.nlm.nih.gov/pubmed/26999089
http://dx.doi.org/10.3390/molecules21030359
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author Law, Betty Yuen Kwan
Mok, Simon Wing Fai
Wu, An Guo
Lam, Christopher Wai Kei
Yu, Margaret Xin Yi
Wong, Vincent Kam Wai
author_facet Law, Betty Yuen Kwan
Mok, Simon Wing Fai
Wu, An Guo
Lam, Christopher Wai Kei
Yu, Margaret Xin Yi
Wong, Vincent Kam Wai
author_sort Law, Betty Yuen Kwan
collection PubMed
description Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM). For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri), Hu Zhang (Rhizoma polygoni cuspidati), Donglingcao (Rabdosia rubesens), Hou po (Cortex magnoliae officinalis) and Chuan xiong (Rhizoma chuanxiong) modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases.
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spelling pubmed-62742282018-12-28 New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy Law, Betty Yuen Kwan Mok, Simon Wing Fai Wu, An Guo Lam, Christopher Wai Kei Yu, Margaret Xin Yi Wong, Vincent Kam Wai Molecules Review Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM). For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri), Hu Zhang (Rhizoma polygoni cuspidati), Donglingcao (Rabdosia rubesens), Hou po (Cortex magnoliae officinalis) and Chuan xiong (Rhizoma chuanxiong) modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases. MDPI 2016-03-17 /pmc/articles/PMC6274228/ /pubmed/26999089 http://dx.doi.org/10.3390/molecules21030359 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Law, Betty Yuen Kwan
Mok, Simon Wing Fai
Wu, An Guo
Lam, Christopher Wai Kei
Yu, Margaret Xin Yi
Wong, Vincent Kam Wai
New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title_full New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title_fullStr New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title_full_unstemmed New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title_short New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy
title_sort new potential pharmacological functions of chinese herbal medicines via regulation of autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274228/
https://www.ncbi.nlm.nih.gov/pubmed/26999089
http://dx.doi.org/10.3390/molecules21030359
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