Taxanes in the Treatment of Advanced Gastric Cancer

Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit t...

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Detalles Bibliográficos
Autores principales: Kang, Byung Woog, Kwon, Oh-Kyoung, Chung, Ho Young, Yu, Wansik, Kim, Jong Gwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274234/
https://www.ncbi.nlm.nih.gov/pubmed/27196887
http://dx.doi.org/10.3390/molecules21050651
Descripción
Sumario:Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC.

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