Taxanes in the Treatment of Advanced Gastric Cancer

Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit t...

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Autores principales: Kang, Byung Woog, Kwon, Oh-Kyoung, Chung, Ho Young, Yu, Wansik, Kim, Jong Gwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274234/
https://www.ncbi.nlm.nih.gov/pubmed/27196887
http://dx.doi.org/10.3390/molecules21050651
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author Kang, Byung Woog
Kwon, Oh-Kyoung
Chung, Ho Young
Yu, Wansik
Kim, Jong Gwang
author_facet Kang, Byung Woog
Kwon, Oh-Kyoung
Chung, Ho Young
Yu, Wansik
Kim, Jong Gwang
author_sort Kang, Byung Woog
collection PubMed
description Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC.
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spelling pubmed-62742342018-12-28 Taxanes in the Treatment of Advanced Gastric Cancer Kang, Byung Woog Kwon, Oh-Kyoung Chung, Ho Young Yu, Wansik Kim, Jong Gwang Molecules Review Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC. MDPI 2016-05-17 /pmc/articles/PMC6274234/ /pubmed/27196887 http://dx.doi.org/10.3390/molecules21050651 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kang, Byung Woog
Kwon, Oh-Kyoung
Chung, Ho Young
Yu, Wansik
Kim, Jong Gwang
Taxanes in the Treatment of Advanced Gastric Cancer
title Taxanes in the Treatment of Advanced Gastric Cancer
title_full Taxanes in the Treatment of Advanced Gastric Cancer
title_fullStr Taxanes in the Treatment of Advanced Gastric Cancer
title_full_unstemmed Taxanes in the Treatment of Advanced Gastric Cancer
title_short Taxanes in the Treatment of Advanced Gastric Cancer
title_sort taxanes in the treatment of advanced gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274234/
https://www.ncbi.nlm.nih.gov/pubmed/27196887
http://dx.doi.org/10.3390/molecules21050651
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