Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds wer...

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Detalles Bibliográficos
Autores principales: He, Haibing, Ge, Yinghua, Dai, Hong, Cui, Song, Ye, Fei, Jin, Jia, Shi, Yujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274251/
https://www.ncbi.nlm.nih.gov/pubmed/27999292
http://dx.doi.org/10.3390/molecules21121722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274251/
https://www.ncbi.nlm.nih.gov/pubmed/27999292
http://dx.doi.org/10.3390/molecules21121722

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