Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica

Two new secondary metabolites, endomeketals A–B (1–2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive sp...

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Detalles Bibliográficos
Autores principales: Sun, Zhang-Hua, Li, Hao-Hua, Liang, Fa-Liang, Chen, Yu-Chan, Liu, Hong-Xin, Li, Sai-Ni, Tan, Guo-Hui, Zhang, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274285/
https://www.ncbi.nlm.nih.gov/pubmed/27447605
http://dx.doi.org/10.3390/molecules21070943
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author Sun, Zhang-Hua
Li, Hao-Hua
Liang, Fa-Liang
Chen, Yu-Chan
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
author_facet Sun, Zhang-Hua
Li, Hao-Hua
Liang, Fa-Liang
Chen, Yu-Chan
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
author_sort Sun, Zhang-Hua
collection PubMed
description Two new secondary metabolites, endomeketals A–B (1–2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. However, no compound showed cytotoxic activity against these human tumor cell lines.
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spelling pubmed-62742852018-12-28 Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica Sun, Zhang-Hua Li, Hao-Hua Liang, Fa-Liang Chen, Yu-Chan Liu, Hong-Xin Li, Sai-Ni Tan, Guo-Hui Zhang, Wei-Min Molecules Communication Two new secondary metabolites, endomeketals A–B (1–2), a new natural product (3), and a known compound (4) were isolated from the ethyl acetate extract of the endophytic fungus Endomelanconiopsis endophytica A326 derived from Ficus hirta. Their structures were determined on the basis of extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. However, no compound showed cytotoxic activity against these human tumor cell lines. MDPI 2016-07-20 /pmc/articles/PMC6274285/ /pubmed/27447605 http://dx.doi.org/10.3390/molecules21070943 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Sun, Zhang-Hua
Li, Hao-Hua
Liang, Fa-Liang
Chen, Yu-Chan
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title_full Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title_fullStr Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title_full_unstemmed Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title_short Two New Secondary Metabolites from the Endophytic Fungus Endomelanconiopsis endophytica
title_sort two new secondary metabolites from the endophytic fungus endomelanconiopsis endophytica
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274285/
https://www.ncbi.nlm.nih.gov/pubmed/27447605
http://dx.doi.org/10.3390/molecules21070943
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