Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration

In the search for prodrug analogs of clopidogrel with improved metabolic characteristics and antiplatelet bioactivity, a group of clopidogrel and vicagrel analogs selectively deuterated at the benzylic methyl ester group were synthesized, characterized, and evaluated. The compounds included clopidog...

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Detalles Bibliográficos
Autores principales: Xu, Xueyu, Zhao, Xue, Yang, Zhichao, Wang, Hao, Meng, Xiangjun, Su, Chong, Liu, Mingyuan, Fawcett, John Paul, Yang, Yan, Gu, Jingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274316/
https://www.ncbi.nlm.nih.gov/pubmed/27248988
http://dx.doi.org/10.3390/molecules21060704

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