Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysi...

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Detalles Bibliográficos
Autores principales: Zhao, Huan, Peng, Qinghua, Han, Zhuzhen, Yang, Li, Wang, Zhengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274321/
https://www.ncbi.nlm.nih.gov/pubmed/26927050
http://dx.doi.org/10.3390/molecules21030281
Descripción
Sumario:Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC(50) value of 8.1 μM.

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