Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysi...

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Autores principales: Zhao, Huan, Peng, Qinghua, Han, Zhuzhen, Yang, Li, Wang, Zhengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274321/
https://www.ncbi.nlm.nih.gov/pubmed/26927050
http://dx.doi.org/10.3390/molecules21030281
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author Zhao, Huan
Peng, Qinghua
Han, Zhuzhen
Yang, Li
Wang, Zhengtao
author_facet Zhao, Huan
Peng, Qinghua
Han, Zhuzhen
Yang, Li
Wang, Zhengtao
author_sort Zhao, Huan
collection PubMed
description Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC(50) value of 8.1 μM.
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spelling pubmed-62743212018-12-28 Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood Zhao, Huan Peng, Qinghua Han, Zhuzhen Yang, Li Wang, Zhengtao Molecules Article Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC(50) value of 8.1 μM. MDPI 2016-02-27 /pmc/articles/PMC6274321/ /pubmed/26927050 http://dx.doi.org/10.3390/molecules21030281 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Huan
Peng, Qinghua
Han, Zhuzhen
Yang, Li
Wang, Zhengtao
Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title_full Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title_fullStr Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title_full_unstemmed Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title_short Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
title_sort three new sesquiterpenoids and one new sesquiterpenoid derivative from chinese eaglewood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274321/
https://www.ncbi.nlm.nih.gov/pubmed/26927050
http://dx.doi.org/10.3390/molecules21030281
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