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Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita
Natural products, known for their medicinal properties since antiquity, are continuously being studied for their biological properties. In the present study, we analyzed the composition of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274325/ https://www.ncbi.nlm.nih.gov/pubmed/27537869 http://dx.doi.org/10.3390/molecules21081069 |
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author | Fitsiou, Eleni Mitropoulou, Gregoria Spyridopoulou, Katerina Tiptiri-Kourpeti, Angeliki Vamvakias, Manolis Bardouki, Haido Panayiotidis, Mihalis Ι. Galanis, Alex Kourkoutas, Yiannis Chlichlia, Katerina Pappa, Aglaia |
author_facet | Fitsiou, Eleni Mitropoulou, Gregoria Spyridopoulou, Katerina Tiptiri-Kourpeti, Angeliki Vamvakias, Manolis Bardouki, Haido Panayiotidis, Mihalis Ι. Galanis, Alex Kourkoutas, Yiannis Chlichlia, Katerina Pappa, Aglaia |
author_sort | Fitsiou, Eleni |
collection | PubMed |
description | Natural products, known for their medicinal properties since antiquity, are continuously being studied for their biological properties. In the present study, we analyzed the composition of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise) and Fortunella margarita (kumquat). GC/MS analyses revealed that the major components in the essential oil fractions, were carvone (85.4%) in spearmint, methyl chavicol (74.9%) in sweet basil, trans-anethole (88.1%) in anise, and limonene (93.8%) in kumquat. We further explored their biological potential by studying their antimicrobial, antioxidant and antiproliferative activities. Only the essential oils from spearmint and sweet basil demonstrated cytotoxicity against common foodborne bacteria, while all preparations were active against the fungi Saccharomyces cerevisiae and Aspergillus niger. Antioxidant evaluation by DPPH and ABTS radical scavenging activity assays revealed a variable degree of antioxidant potency. Finally, their antiproliferative potential was tested against a panel of human cancer cell lines and evaluated by using the sulforhodamine B (SRB) assay. All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma. |
format | Online Article Text |
id | pubmed-6274325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62743252018-12-28 Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita Fitsiou, Eleni Mitropoulou, Gregoria Spyridopoulou, Katerina Tiptiri-Kourpeti, Angeliki Vamvakias, Manolis Bardouki, Haido Panayiotidis, Mihalis Ι. Galanis, Alex Kourkoutas, Yiannis Chlichlia, Katerina Pappa, Aglaia Molecules Article Natural products, known for their medicinal properties since antiquity, are continuously being studied for their biological properties. In the present study, we analyzed the composition of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise) and Fortunella margarita (kumquat). GC/MS analyses revealed that the major components in the essential oil fractions, were carvone (85.4%) in spearmint, methyl chavicol (74.9%) in sweet basil, trans-anethole (88.1%) in anise, and limonene (93.8%) in kumquat. We further explored their biological potential by studying their antimicrobial, antioxidant and antiproliferative activities. Only the essential oils from spearmint and sweet basil demonstrated cytotoxicity against common foodborne bacteria, while all preparations were active against the fungi Saccharomyces cerevisiae and Aspergillus niger. Antioxidant evaluation by DPPH and ABTS radical scavenging activity assays revealed a variable degree of antioxidant potency. Finally, their antiproliferative potential was tested against a panel of human cancer cell lines and evaluated by using the sulforhodamine B (SRB) assay. All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma. MDPI 2016-08-16 /pmc/articles/PMC6274325/ /pubmed/27537869 http://dx.doi.org/10.3390/molecules21081069 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fitsiou, Eleni Mitropoulou, Gregoria Spyridopoulou, Katerina Tiptiri-Kourpeti, Angeliki Vamvakias, Manolis Bardouki, Haido Panayiotidis, Mihalis Ι. Galanis, Alex Kourkoutas, Yiannis Chlichlia, Katerina Pappa, Aglaia Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title | Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title_full | Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title_fullStr | Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title_full_unstemmed | Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title_short | Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita |
title_sort | phytochemical profile and evaluation of the biological activities of essential oils derived from the greek aromatic plant species ocimum basilicum, mentha spicata, pimpinella anisum and fortunella margarita |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274325/ https://www.ncbi.nlm.nih.gov/pubmed/27537869 http://dx.doi.org/10.3390/molecules21081069 |
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